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2007, Lab on a Chip
Ultrasound in Medicine & Biology
Precision Manufacture of Phase-Change Perfluorocarbon Droplets Using Microfluidics2011 •
Biotechnology Progress
Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy2009 •
Bubble science engineering and technology
Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing2010 •
Lipid-encapsulated microbubbles are used as contrast agents in ultrasound imaging. Currently available commercially made contrast agents have a polydisperse size distribution. It has been hypothesised that improved imaging sensitivity could be achieved with a uniform microbubble radius. We have recently developed microfluidics technology to produce contrast agents with a nearly monodisperse distribution. In this manuscript, we analyze echo responses from individual microbubbles from monodisperse populations in order to establish the relationship between scattered echo, microbubble radius, and excitation frequency. Simulations of bubble response from a modified Rayleigh-Plesset type model corroborate experimental data. Results indicate that microbubble echo response can be greatly increased by optimal combinations of microbubble radius and acoustic excitation frequency. These results may have a significant impact in the formulation of contrast agents to improve ultrasonic sensitivity.
2008 •
Molecular imaging
Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imagingEncapsulated microbubble contrast agents incorporating an adhesion ligand in the microbubble shell are used for molecular imaging with ultrasound. Currently available microbubble agents are produced with techniques that result in a large size variance. Detection of these contrast agents depends on properties related to the microbubble diameter such as resonant frequency, and current ultrasound imaging systems have bandwidth limits that reduce their sensitivity to a polydisperse contrast agent population. For ultrasonic molecular imaging, in which only a limited number of targeted contrast agents may be retained at the site of pathology, it is important to optimize the sensitivity of the imaging system to the entire population of contrast agent. This article presents contrast agents with a narrow size distribution that are targeted for molecular imaging applications. The production of a functionalized, lipid-encapsulated, microbubble contrast agent with a monodisperse population is d...
In this paper, we describe a technique for producing populations of ultrasound contrast agents (UCA) with a narrow size distribution. Using acoustic techniques, we measure the frequency-dependent attenuation coefficient for suspensions of ultrasound contrast agents with varying size distributions, ranging from narrow to wide. Our results demonstrate that as the size distribution becomes more uniform, attenuation occurs within a narrow frequency range. Additionally, as the mean size decreases, the peak in the attenuation coefficient occurs at a higher frequency.
Review of Scientific Instruments
Horizon: Microfluidic platform for the production of therapeutic microbubbles and nanobubblesLoading Preview
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Langmuir
Long-Term Stability by Lipid Coating Monodisperse Microbubbles Formed by a Flow-Focusing Device2006 •
2012 •
Ultrasound in Medicine & Biology
Needle Size and Injection Rate Impact Microbubble Contrast Agent Population2008 •
Current Pharmaceutical Biotechnology
Ultrasound and Microbubble Guided Drug Delivery: Mechanistic Understanding and Clinical Implications2014 •
Langmuir
Formation of Protein and Protein–Gold Nanoparticle Stabilized Microbubbles by Pressurized Gyration2015 •
2011 •
Ultrasound in medicine & biology
Growth and dissolution of an encapsulated contrast microbubble: effects of encapsulation permeability2009 •
Annual Review of Fluid Mechanics
Generation of Microbubbles with Applications to Industry and Medicine2015 •
Ultrasound in Medicine & Biology
Initial Investigation of Acoustic Droplet Vaporization for Occlusion in Canine Kidney2010 •
2008 •
Ultrasound in medicine …
Delivery of Chlorambucil Using an Acoustically-Triggered Perfluoropentane Emulsion2010 •
Ultrasound in Medicine & Biology
Effect of Microbubble Size on Fundamental Mode High Frequency Ultrasound Imaging in Mice2010 •
Journal of Fluids Engineering
An Experimental Review on Microbubble Generation to be Used in Echo-Particle Image Velocimetry Method to Determine the Pipe Flow Velocity2013 •
Journal of Controlled Release
Acoustically-active microbubbles conjugated to liposomes: Characterization of a proposed drug delivery vehicle2007 •
Biomaterials
In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive contrast agents2013 •
Pharmaceutical Research
Delivery of Water-Soluble Drugs Using Acoustically Triggered Perfluorocarbon Double Emulsions2010 •
Colloids and Surfaces B: Biointerfaces
Probing phospholipid microbubbles by atomic force microscopy to quantify bubble mechanics and nanostructural shell propertiesBubble Science, Engineering & Technology
Microbubble compositions, properties and biomedical applications2009 •
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Plane-Wave Contrast Imaging: A Radiation Force Point of ViewJournal of Controlled …
Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow2009 •
Journal of Colloid and Interface Science
Microbubble size isolation by differential centrifugation2009 •
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
The role of inertial cavitation in acoustic droplet vaporization2000 •
Langmuir
Microfluidic Fabrication of Stable Gas-Filled Microcapsules for Acoustic Contrast Enhancement2013 •
The Journal of the Acoustical Society of America
Investigating the effect of fabrication method on the stability and acoustic response of microbubble agents2013 •
2014 •
Journal of Hydrodynamics, Ser. B
Modeling microbubble dynamics in biomedical applications2012 •
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
Increasing the sonoporation efficiency of targeted polydisperse microbubble populations using chirp excitation2000 •
2008 •